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An insufficient intake of fruits, vegetables, and fiber-rich foods has also been associated with an elevated risk of UFs

In this study, the transcription levels of genes associated with Hippo signaling, such as Yap1 and Wwc1 , were higher in APAP group than in CON group, while BSL-pretreatment partially reversed the elevated expression owing to APAP

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This complexity underscores the need for stage-specific interventions: acute mitochondrial injury may respond to antioxidants or metabolic substrates, while advanced disease may require reprogramming of cellular bioenergetics

Symptoms often shift during perimenopause and menopause , especially in women with high estrogen or unresolved immune triggers