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Dhrmann S, Cole JN, Nizet V (2016) Conquering neutrophils

For 10unit (0.10 mL) administrations during titration, consider 30 or 50unit insulin syringes for improved readability

Labwork at that time was notable for an elevated uric acid of 10.6mg/dl (reference range: 3.5 - 8.5 mg/dl.) Out of concern for TLS precipitating hyperuricemia in the setting of a high-grade tumor in addition to starting a new chemotherapy regimen, the patient was additionally given 10mg of rasburicase and started on 300mg of allopurinol daily

Amgen has begun recruiting for its next phase 2 trial with AMG-133, which will aim to understand AMG-133's efficacy in more patients over a longer period of time 2

Restoring GSH homeostasis could therefore help counteract redox imbalance and represents a potential therapeutic or prophylactic strategy that warrants further investigation