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j)Double-boiler with agitation Dubnoff FANEN, model 145 3.2 METHODS 3.2.1 RESEARCH METHODOLOGY The research made use of the homeopathic medicine Arsenicum album, cuprum metallicum, zincum metallicum and manganum, in order to check their antioxidant action in rats brain homogenate, comparatively to the melatonin, adopted as a positive patern because it is a mighty antioxidant in vitro

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98 An additional phase 3 study with exa-cel demonstrated transfusion independence achieved in 32 of 35 treated patients with -thalassaemia

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In preclinical studies, HG inhalation mitigated oxidative stress and NLRP3 pyroptosis and HG is shown to decrease both the degree of mitochondrial swelling and loss of mitochondrial membrane potential while also preserving mitochondrial cytochrome c content [9, 31]

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