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Hearts were excised with heparin (30 g/kg, intraperitoneally), weighed and the entire heart from base to apex was cut into 1-mm-thick slices along the short axial plane

The protein expression of TIMP-1 was decreased in the CS group when compared with the control group, whereas pretreatment with medium and high dosages of GHK-Cu increased it when compared to the CS group (Figures 2B,D)

In contrast, when tissue folate or cobalamin stores are intact (Silberberg et al, 1997) or in the case of an alteration of the transsulfuration pathway dependent on vitamin B 6 deficiency or on heterozygosity for a CBS defect (Bostom et al, 1995a), an excessive methionine supply might lead to an important elevation of plasma homocysteine

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Bender, A., Hajieva, P

Yang L, Wang H, Liu L et al (2018) The role of insulin/IGF-1/PI3K/Akt/GSK3 signaling in Parkinsons disease dementia