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Neurodegeneration Neurodegeneration is the loss of function and death of neurons in the nervous system

However, there are no large-scale, long-term human safety trials

10.3402/jev.v5.31053 126 KrutZ.PelledG.GazitD.GazitZ

Regarding therapeutic strategies involving SAMe supplementation, overexpression or inhibition of methionine cycle enzymes (MAT1A, MAT2A) [177,250,259] and synergistic therapies with chemotherapeutic agents have shown significant promise in preclinical studies