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A randomized phase II study evaluating pyridoxine for the prevention of hand-foot syndrome associated with capecitabine therapy for advanced or metastatic breast cancer

Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues

Some common side effects include nasal congestion, headaches, priapism, and flushing, and they may be less effective for patients with hypogonadism, vascular disease, or diabetes, which might require the use of either ICP or alternative treatments like shockwave therapy and vacuum erectile devices

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Thus, at present, its clinical utility is limited and not well-characterized

SYK activates the downstream AKT pathway and induces the upregulation of MCL-1 expression, resulting in cell survival and migration [32]