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The medication increases photosensitivity by 30-50%, making skin burn faster even with brief sun exposure, requiring SPF 30+ sunscreen reapplication every 2 hours

According to these criteria, a family must have at least three members diagnosed with cancers associated with LS, with at least one being a first-degree relative of the other two

This site-specific conjugation strategy, targeting the hinge cysteine residues, enables the generation of a highly homogeneous ADC population with a controlled DAR of 23, as characterized by hydrophobic interaction chromatography (HIC), minimizing the heterogeneity and aggregation risks common with stochastic conjugation methods [54]