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AOD-9604 was designed to replicate GH's lipolytic effects without affecting blood glucose or promoting tissue growth, targeting fat breakdown directly

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Research progress Support The animal experiments have achieved remarkable results: In the obese mouse model, after daily subcutaneous injection of AOD 9604 (250 g/kg) for 8 weeks, the body weight of the mice decreased by 12%, the subcutaneous fat mass decreased by 25%, and the weight of epididymal adipose tissue significantly decreased, confirming its effectiveness in fat reduction

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For example, research published in Obesity indicated some modest weight reduction effects in overweight individuals

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The second mechanism involves inhibition of clonogenic cell growth, potentially via downregulation of RRM2 and DNA damage, leading to accumulation of DNA breaks and cell cycle blockade

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