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Mahmoudiasl GR, Abbaszadeh HA, Rezaei-Tavirani M, Abdollahifar MA, Sadeghi Y, Khoramgah MS, et al

Interestingly, triptolide is found to enhance the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in pancreatic cancer cells by autophagy activation through Pumilio RNA-binding family member 1 (PUM1) downregulation, suggesting a potential strategy to increase tumor sensitivity to TRAIL [995]

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When volume is lost here through the progressive loss of subcutaneous fat, muscle and bone that characterises ageing in the face the effect radiates outward: the temples appear sunken and concave, the skin overlying the area becomes more thinly supported and shadowed, the tail of the brow loses its lateral support and descends, and the overall upper face takes on a hollowed, drawn and aged appearance

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