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The availability of methionine, folate, vitamin B12, and betaine influences the rate of homocysteine remethylation, while the transsulfuration pathway acts as a buffer to prevent homocysteine accumulation

Cleavage of polyhistidine from the protein is normally not attempted unless the protein is used as a drug in humans or animals

It operates in concert with two additional receptor pathways, amplifying effects that a single agonist could never achieve on its own

doi: 10.1186/1471-2164-14-867

2a) that are directly downstream of the pMEK (Fig