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In these studies, the maximum tolerated dose of simvastatin was defined to be 15 mg/kg/day, 25-fold higher compared to a typical dose

Oxidative phosphorylation impairment by DDT and DDE

Maintaining adequate levels of glutathione is important for managing the bodys response to any potential toxins vaccines might introduce (14,15,16)

ROS are capable of oxidizing proteins, pigments, lipids, nucleic acids, and other cell molecules, disrupting their functional activity

For example, the excessive activation of ferritinophagy, lipophagy, clock autophagy, and CMA can promote ferroptosis by degrading iron proteins, lipid droplets, circadian rhythm regulators, and GPX4, respectively (Honma et al., 2023

10.7150/jca.57054 173 ZhangW.NingN.HuangJ