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IGF-1 mediates many of growth hormones anabolic effects, including muscle protein synthesis, bone growth, cartilage formation, and cellular proliferation

Natural killer T cells protect against liver injury, and natural killer T cell-deficient mice exhibit high susceptibility to APAP-induced liver damage 5

NF-B pathway Nuclear factor-B (NF-B) is a redox-sensitive transcription factor that is regulated by ROS through the classical IkB kinase (IKK)-dependent canonical pathway (Liu et al., 2017) and coordinates innate and adaptive immunity, inflammation, and apoptosis (Piette et al., 1997)

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