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Although three representative mutations identified in the three largest pedigrees of 5-reductase-2 deficiency are described above, there are documented mutations in all five exons of the gene, ranging from a single point defect to a deletion of the entire gene as noted in Figure 1(1, 4, 5)

Additionally, experimental models with inner ears directly inoculated with pathogenic viruses do not always show hearing loss and if they do it is often a progressive rather than sudden loss [74, 75]

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These mice develop delayed aging features: progression of the age-related hearing loss is slowed down [89], and senile changes in the salivary glands are less pronounced [90]

Pearce, Metabolic pathways in immune cell activation and quiescence