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U-2OS and KHOS-24OS cells were cultured in 90% RPMI-1640 containing 10% FBS

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Munc18-1 deficient mice were generated as described previously (de Vries et al., 2000)

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The neutral polysaccharides of astragalus could also promote the nuclear localization of daf-16 and prolong Caenorhabditis elegans lifespan via the IIS pathway (Yuan Y

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