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The views expressed in this paper are those of the authors and do not necessarily represent the views of the US Department of Veterans Affairs or the US government

For clinicians working in endocrinology, metabolic medicine, or hormone optimization, this combination merits evaluation within a structured clinical framework: comprehensive pre-treatment assessment, individualized dosing based on patient physiology, regular IGF-1 monitoring, and integration with broader hormonal and metabolic management

Native IGF-1 has 10-20 minute half-life, strong IGFBP binding limiting bioavailability, primarily local autocrine/paracrine actions, and rapid clearance

These hormones also contribute to improved recovery, energy, and metabolism