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The fasting duration and the time intervals between metformin gavage and subsequent procedures on the IPGTT day, as well as on the FDG injection measurement day, were the same as in the previous metformin experiment

All animal procedures were approved by the Animal Care and Use Committee of Sun Yat-Sen University (SYSU-IACUC-2021-000158)

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It is evident that disorders of glucose metabolism in the form of diabetes and IR are the core elements of the MetS