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Local rashes most often come from three mechanisms: An immune response to the medication itself, sending histamine to the injection area Sensitivity to an inactive ingredient like a preservative or buffer in the formulation Mechanical trauma from the needle or a fast injection technique The immune explanation is straightforward: a neighborhood-level alarm that sends histamine and inflammatory signals, producing redness and itch

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staff at the Mass Spectrometry Resource Laboratory in the Center for Advanced Research Technologies (CART) and the Histology, Biochemistry, and Molecular Imaging (HBMI) Core at the Center for Musculoskeletal Research (CMSR) at URMC, the Proteomics/Metabolomics Core at Moffitt Cancer Center, which is funded in part by Moffitts Cancer Center Support Grant (P30CA076292), and University of Chicago Metabolomics Platform (RRID: SCR_022932)

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