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Methods: This review synthesizes current evidence on the protective roles of bilirubin against PD, detailing its mechanisms in countering oxidative stress, modulating neuroinflammation, inhibiting ferroptosis, and supporting normal development of nigrostriatal dopaminergic circuits

Ferroptosis is a form of apoptosis that relies on intracellular iron [14]

Pratic D

doi: 10.15761/icst.1000228

J Neurochem 61(4):14381444 Saha L, Bhandari S, Bhatia A, Banerjee D, Chakrabarti A (2014) Anti-kindling effect of bezafibrate, a peroxisome proliferator-activated receptors alpha agonist, in pentylenetetrazole induced kindling seizure model

Not because hormones are the only factor, but because if your hormones are chaotic, nothing else will work optimally