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This implies that in these critically ill patients, probably, the effect of low erythropoietin on hepcidin synthesis was minor/secondary and other hepcidin-regulating factors took precedence, resulting in hepcidin downregulation

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Rats were kept in the Laboratory Animal Center of the Sir Run Run Shaw Hospital, in a temperature-controlled and humidity-controlled environment under a controlled diurnal 12 h light/dark cycle with free access to food and water