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Studies have shown that SCOT1 knockout mice exhibit more severe cardiac structural and functional impairments during heart failure ( Under non-fasting conditions, the myocardium rarely takes up ketone bodies and primarily relies on fatty acid oxidation (FAO) and glucose oxidation for energy (Ho et al., 2019), but when circulating ketone bodies increase, the heart preferentially utilizes ketone bodies for energy while reducing FAO and glucose oxidation (Stanley et al., 2003

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doi: 10.1016/j.microb.2025.100310 148