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Furthermore, Gpx4 knockout in regulatory T cells can suppress tumors, while selenium supplementation can enhance the survival of Tfh cells and improve immune capacity [95]

J Hematol Oncol 15:10 Peng B, Shi RF, Bian J, Li YW, Wang PP, Wang HL, Liao J, Zhu WG, Xu XZ (2021) PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair

Critical safety thresholds have been established for compounds like EGCG (800 mg/day limit) (240) and -carotene (contraindicated in smokers), while hepatotoxicity cases linked to curcumin formulations have prompted regulatory warnings across multiple jurisdictions

Freckman DW, Caswell EP

The main mechanism of development of hyperthyroidism, according to Eckstein et al

GPX4 deficiency also triggers ferroptosis in B1 and marginal zone (MZ) B cells, potentially contributing to tumorigenesis [121]