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The World Health Organizations current classification approach for glioblastoma is mainly based on mutation of isocitrate dehydrogenase [24]

a cytostatic or antineoplastic agent

These reactions are rare but serious

Consequently, establishing no-observed-adverse-effect levels (NOAEL) (Dorato and Engelhardt, 2005) through standardized toxicokinetic studies is essential for clinical advancement (Dhupal and Chowdhury, 2020