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Abbreviations AD: Adefovir Dipivoxil ASGPR: Asialoglycoprotein receptor HBc: Core protein cccDNA: Covalently closed circular DNA DOCK11: Dedicator of cytokinesis 11 DAAs: Direct-acting antivirals EPR: Enhanced permeability and retention AuNPs: Gold-NPs GQDs: Graphene quantum dots HAV: Hepatitis A Virus HBV: Hepatitis B Virus HbsAg: Hepatitis B Virus surface antigen HCV: Hepatitis C Virus HDV: Hepatitis D Virus HEV: Hepatitis E Virus LNPs: Lipid-based nanoparticles MNPs: Magnetic nanoparticles Ng: NanoGel NPs: Nanoparticles NLCs: Nanostructured lipid carriers PRRs: Pattern recognition receptors PEG: Polyethylene glycol QDs: Quantum dots RNAi: RNA interference AgNPs: Silver nanoparticles siRNA: Small interfering RNA NTCP: Sodium taurocholate Co-transporting polypeptide receptor SLNs: Solid lipid nanoparticles VLPs: Virus-like particles WHO: World Health Organization References Purcell RH