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A modern alternative to antibiotics includes phage therapy and anti-colonization strategies, which provide selective suppression of metabolically unfavorable taxa without significantly disrupting the overall microbiota structure

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Employing digital PCR (dPCR) and next-generation sequencing to longitudinally quantify mtDNA mutations in paired peripheral blood, tissue biopsies, and CSF will clarify their roles in residual inflammation, neurocognitive decline, and immunological failure