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& Berndt, C

Biessen, E

As an example for the latter role, calcium released locally around lysosomes in response to cell stress activates calcineurin, which dephosphorylates the lysosome-docked transcription factors TFEB and TFE3 and enables their translocation to the nucleus 195

Our role is to evaluate whether the potential benefit justifies the uncertainty for a given patient, to monitor closely, and to stop if it is not the right fit