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The absence of precise knowledge regarding the mechanisms underlying the development and progression of neuronal damage and neurodegeneration, along with the identification of biochemical factors, specific antigens or proteins involved in these processes, complicates their establishment in experimental animal models

Three major classes of lipid peroxidaseslipoxygenases (ALOXs), cyclooxygenases (COXs), and cytochrome P450 reductase (POR)are dysregulated in AD (302)

doi: 10.3390/pathophysiology29030039 40 KanczkowskiWBeuschleinFBornsteinSR

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