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Nevertheless, its application has been linked to severe adverse effects, particularly reproductive toxicity

In patients in the placebo-controlled studies of STS 6 mg/24 hours, the only adverse event with an incidence of twice that of the placebo group was application site reaction.55 In higher-dose studies (9 mg/24 hours or 12 mg/24 hours), adverse events with an incidence of at least twice that of placebo included insomnia (32% vs 7%), dry mouth (13% vs 6%), dizziness (14% vs 5%), nervousness (10% vs 4%), and abnormal dreams (5% vs 2%).55 Most adverse events were considered mild or moderate