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It also reduced the increase of total oxidative stress (TSO), oxidative stress index (OSI) and bladder tissues undergo apoptosis

Pyruvate dehydrogenase kinase (PDK) inhibits PDH activity by phosphorylating PDHA1 [19], whereas pyruvate dehydrogenase phosphatase (PDP) restores PDH function by dephosphorylating PDHA1[20]

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Furthermore, GSH has an overall negative charge at physiological pH and mitochondria exhibit a large negative membrane potential

administered alpha-melittin nanoparticles (-MEL-NPs) and injected intravenously with a concentration of 20 mg/kg which showed the growth inhibition of B16F10 (human melanoma cells) and have no toxic effects on normal cells (209)

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