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Larger doses of either Tylenol or alcohol, and especially both at the same time, can also increase the risk and severity of the side effects and risks

Uncommon (affects 110 in 1,000 people): joint pain, tingling in fingers, or water retention in hands and feet

Any side effects are usually mild and temporary, such as a feeling of internal warmth, localized flushing, mild chest pressure, or light nausea during the infusion

J Pharmacol Exp Ther 241:527533 Roberts DW, Bucci TJ, Benson RW, Warbritton AR, McRae TA, Pumford NR, Hinson JA (1991) Immunohistochemical localization and quantification of the 3-(Cystein- S -yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity