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Tirzepatide may produce greater average weight loss for some individuals because it activates two hormone pathways, GLP-1 and GIP, while semaglutide targets only the GLP-1 receptor

[DOI] [PMC free article] [PubMed] [Google Scholar] 209.Xu, Q

Mechanism of Action: The FOXO4-p53 Axis In senescent cells, the transcription factor FOXO4 is upregulated and stabilized via the CHK2-USP37 axis, where the deubiquitinase USP37 prevents its proteasomal degradation (PNAS, 2026)