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However, B 12 deficiency after gastric surgery does not usually become a clinical issue

Of special relevance to our study, RNR consumes reducing equivalents supplied by GSH, as well as thioredoxin, in mammalian cells (Zahedi Avval & Holmgren, 2009

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Electron transport through the complexes is coupled to proton translocation via the mitochondrial inter membrane space, forming an electrochemical proton gradient (electromotive force) and a mitochondrial transmembrane potential ( m ), necessary for generation of ATP