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The FDA has not approved MOTS-c for human use, and in 2023, the agency clarified that it cannot legally be used in compounded medications

Immune Senescence, Immunosenescence and Aging

doi: 10.1007/s00702-004-0200-5 149 KrauseDWeidingerEDippelCRiedelMSchwarzMJMllerNet al

Some research suggests that the molecular mechanism of transition between acute and chronic adaptation to cold stress might prove to be a novel molecular target for the treatment of metabolic disorders, via promoting biogenesis of BAT [50]