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Most protocols last 4-8 weeks followed by rest periods

Animal models can provide us with cues to developmental, physiological and pathophysiological cues, but they are often expensive, ethical concerned laden and do not effectively show human specific responses to diseases or treatments [96]

No one has looked at the adverse effects they might have on humans. Svensson said the lack of information on these peptides is also her biggest issue

Ruetten H, Zabel U, Linz W, Schmidt HH

Cellular mechanisms of Decreased Response Desensitization Downregulation Tachyphylaxis Tolerance Desensitization Desensitization refers to a reduced response to an agonist drug due to over activation of a receptor (high doses, prolonged exposure to agonist)

Miller, C