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Selenoproteins carry out the major nutritional roles of Se and have a range of effects from antioxidant, redox-active, anti-inflammatory, anti-ferroptosis, transport of Se, reduction of endoplasmic reticulum (ER) stress, to the production of active thyroid hormone (Reference Rayman3)

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Effect of Small doses of lodine on thyroid function during caloric restriction in normal subjects

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In perimenopausal women, a decline in circulating E2 levels is associated with a 50-80% increase in ROS production, positioning E2 loss as a key driver of mitochondrial oxidative stress