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The challenges included demonstrating the circadian rhythm of the drug target, creating a drug formulation that replicated that rhythm and then proving benefit in clinical trials

First of all, it is convenient to use it does not require special storage (can be kept in a cabinet), the undissolved peptide (in powder form) is not as unstable as its dissolved form administered by injection, and moreover, the active substance itself has greater bioavailability

What to Expect from B12 Treatment The timeline for B12 injection benefits varies from person to person, but here's what many of our clients experience: Within 24-48 hours: Increased energy and improved mental clarity often appear first

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Image: Dragana Gordic/Getty Images About the Authors Toni Golen, MD, Editor in Chief, Harvard Women's Health Watch