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The results were clear: Type I (skin/scalp enzyme): Copper strongly inhibited activity, with an IC of ~1.9 M and a Ki of ~3.5 M

a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted

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SAM supplies methyl groups for hundreds of reactions involving DNA, phospholipids, neurotransmitter metabolism, creatine synthesis, hormone metabolism and selected detoxification reactions