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Crohns disease, an autoimmune disease, can also result in B12 deficiency

In the group of children with Down syndrome this correlation was not found

In HCT8 cells, cystine transport activity was significantly inhibited by glutamate (Figure 8), indicating the occurrence of system x c in these cells, although the resistant variant (HCT8DDP) had a much higher activity of this system

It depends on the cause of the deficiency, ongoing risk factors, and how well the treatment works

doi:10.1631/jzus.B1100179

However, direct measurements can be complicated to carry out, especially in the field, and in many cases it is more convenient to measure a few important 'state variables' on which the properties depend, and then look up the desired property as a function of the measured state in a table, or calculate it using a mathematical formula