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By applying transcriptomic clocks to the single-cell Tabula Muris data, we found that most cell types, including stem cells, exhibit an increase in biological age and share common pro-aging signatures, such as upregulation of pro-inflammatory chemokine Ccl5 89 and downregulation of modulators of circadian rhythm Dbp 91 and ECM organization Sparc 94

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Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity

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