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The thioredoxin system further contributes to cellular redox buffering, particularly in neurons where copper dysregulation can induce oxidative injury (45)

This contrasts with Percoll whose colloidal silica particles interfere with the smooth migration of macromolecules into the gel

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( TNF- is mainly produced by activated macrophages, NK cells and T lymphocytes

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It does not appear to substantially improve liver injury markers, though it may have favorable effects on adiponectin and insulin levels