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It is not clear the potential reasons of these discrepancies, although it is interesting that multiple IGF-1 signaling pathway molecules are potentially targeted by one miRNA, and studies are required to investigate its relationship with other miRNAs discussed below

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GH Axis Integrity Assessment Tesamorelin stimulation testing is used in pre-clinical research to assess somatotroph secretory reserve characterising peak GH responses as a functional readout of pituitary GH axis integrity across disease models, ageing paradigms, and pharmacological intervention studies

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