l-carnitine and digestive enzymes for weight loss Beneficial effects of supplementation management in overweight obese adults: An updated systematic review and dose-response meta-analysis of randomized controlled trials LEANER YOU- INSTAMELTS FOR WEIGHT

Liu (EPFL) for their helpful comments on the manuscript

Experimental evidence has shown that the overproduction of oxygen and nitrogen free radicals (RNS) is responsible for endothelial dysregulation

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Continuous data with a normal distribution [age, BMI, insomnia duration, GAD-7 score, PHQ-9 score, PSQI score, IGF-1 score, total sleep time, sleep latency, sleep efficiency, rapid eye movement (REM) sleep, stage 1 non-REM (stage N1), stage 2 non-REM (stage N2), stage 3 non-REM (stage N3), stage N1 time, stage N2 time, stage N3 time, REM sleep latency, REM arousal index, arousal index, apnea-hypopnea index (AHI), periodic limb movement index (PLMI), mean SaO 2 , minimum SaO 2 , and end-tidal CO 2 ] were expressed as means and standard deviations and compared among groups by using one-way ANOVA

Weight-based dosing considerations While the standard clinical trial protocols use fixed-dose titration schedules regardless of body weight, some researchers adjust their approach based on body composition

Boutet-Robinet, E., Trouche, D