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ROS can act on proteins to cause side-chain oxidation, backbone fragmentation, unfolding, and misfolding, all resulting in loss of activity [25]

Additionally, pathologies like cancer, diabetes mellitus, cardiovascular diseases, and chronic kidney disease can cause an increase in oxidative stress

BioXCell) as previously described ( Tissue Collection and Histological Assessment Pancreatic tissue was collected and fixed in 4% paraformaldehyde (PFA

Moreover, different risk factors would influence the efficacy of supplements

Currently, there are no data to indicate that dietary supplementation with Vitamins E or Vitamin C alters mortality, or the incidence of cancer in the elderly