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The animals were bred in the animal house of the Department of Biochemistry, Michael Okpara University of Agriculture, Umudike under standard conditions (2527 C, 12 h natural light-dark cycle) and fed with commercially available rat pellets and water ad libitum

Transforming growth factors beta 1 and alpha in chronic liver disease

OA-VI12 was shown to promote the expression of miR-122-5p while downregulating the expression of MITF and TYR, suggesting that it inhibited melanin synthesis through the miR-122-5p/MITF/TYR axis

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