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doi: 10.1042/BSR20230160.Google Scholar Nierenberg, JL, He, J, Li, C et al

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Microsomal estradiol hydroxylation in human breast cancer showed significantly higher 4-hydroxy:2-hydroxyestradiol ratio in tumor tissue than in adjacent normal breast tissue [48], but the breast cancer tissue samples contained fourfold higher levels of 4-hydroxyestradiol (4-OHE 2 ) than in normal tissue from benign breast biopsies [57]

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For all identified candidate gene sequences, we predicted protein subcellular localisation regions using DeepLoc-2.0, 40,87 , which uses protein sequences as input for Neural Networks algorithm trained on Uniprot proteins with experimental evidence