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Therefore, we surmise that the previously unknown transsulfuration reaction with glutathione functions is potentially in synergy to determine thiolated tRNAs levels, thus modulating cellular metabolism

Castela, A., Vendeira, P

In bacteria, the NadA gene encodes quinolinate synthase A (EC 2.5.1.72), an enzyme required for NAD biosynthesis (Foster and Moat, E

The primary antibodies were as follows: kidney injury molecule -1 (Kim-1, 1:200, ab78494,Abcam), glutathione peroxidase 4 (GPX4, 1:100, ab125066, Abcam), ferritin heavy chain 1 (FTH-1, 1:400, 4393, CST), ACSL4 (1:200, 22401-1-AP, Proteintech), cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11, 1:200, 26864-1-AP, Proteintech), GSTT1 (1:200, 15838-1-AP, Proteintech), GSTM1 (1:200, 12412-1-AP, Proteintech) and 4-Hydroxynonenal (4-HNE,1:100,MA5-27570,Thermo Fisher)