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This provided direct evidence of increased lipid peroxidation in the CF airway and strongly suggested that this elevation is a consequence of the pulmonary inflammation characteristic of CF, rather than a direct, inflammation-independent outcome of the primary CF defect

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Thomas DA, Faderl S, Cortes J, OBrien S, Giles F, Garcia-Manero G, Kornblau S, Andreeff M , Beran M, Verstovsek S, Pierce S, Letvak L, Salvado A, Champlin R, Kantarjian H

Viability was assessed 72 h after addition of 4-OH-TAM