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Following a 32-hour incubation, LL-37 was shown to reduce aggregation by up to 80% using a 2-fold excess of S, with binding characteristics found to be similar to PSM3

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Inside the endosome and due to the low pH and ferrireductases (such as six transmembrane epithelial antigen of the prostate 1 [STEAP-1]), Fe 3+ dissociates from the complex and becomes Fe 2+ , which leaves the endosome through the transporter divalent metal transporter 1 (DMT1) ( Figure 1 )