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A compromised gut barrier is both a cause and a consequence of dysbiosis, and intervening at the level of mucosal integrity, which is precisely what BPC-157 does in animal models, represents a mechanistically coherent approach to gut-mediated systemic aging

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doi: 10.1146/annurev-pathmechdis-012418-012718 26 MurrayPJAllenJEBiswasSKFisherEAGilroyDWGoerdtSet al

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This induction of HIF1 expression occurs through EZH2-dependent suppression of PHD3 expression (8 in Fig

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