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In newborn screenings where biochemical markers are indicative of vitamin B 12 deficiency, the diagnosis of inborn errors of vitamin B 12 metabolism is performed via functional studies on cultured fibroblasts isolated from skin biopsies (Watkins and Rosenblatt, 2013) or via molecular genetic analysis of putative genes

doi: 10.1016/j.bbrc.2003.10.075 58 AdamouJHeinrichsJErwinAWalshWGayleTDormitzerMet al

For instance, flexible polylactic acid (FPLA) scaffolds with adjustable viscoelasticity, tensile strength, and compressive modulus have been designed to match the properties of natural IVDs (Figure 5)

Outcomes (O): haematological parameters i.e

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Avoid direct contact with eyes , if contact occurs rinse well with lukewarm water