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6 Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCSF, San Francisco, California, USA

Passive smoking has been found to be a risk factor for development of sensitization in children (Halken et al., 1995)

Although these elements might support the autoinflammatory nature of AS, studies demonstrating the presence of autoantibodies (such as anti-CD74, anti-sclerostin and anti-noggin antibodies) and evidence of activation and clonal expansion of T cell populations support an autoimmune component to the disease